Clayton M. Smith, M.D., F.A.C.P.
Areas of Interest
Gender-Affirming Care for Transgender/Non-Binary People | HIV Pre-Exposure Prophylaxis | Internal Medicine
Primary Practice Location
UofL Physicians – Primary Care
UofL Health – Chestnut Street Outpatient Center
401 East Chestnut Street, Suite 370
Louisville, KY 40202
502-588-4500 Get Directions
UofL Health – Chestnut Street Outpatient Center
401 East Chestnut Street, Suite 370
Louisville, KY 40202
502-588-4500 Get Directions
Get to know
Clayton M. Smith, M.D., F.A.C.P.
Clayton M. Smith, M.D., F.A.C.P., is an associate professor of medicine and chief of the division of general internal medicine, palliative medicine and medical education. He graduated from the University of Miami Miller School of Medicine in 2009 and completed residency training at the University of Louisville in 2012.Education & Training
B.A.
Tulane University | New Orleans | 2005
Tulane University | New Orleans | 2005
M.D.
University of Miami Miller School of Medicine | Miami | 2009
University of Miami Miller School of Medicine | Miami | 2009
Internship
University of Louisville School of Medicine | Internal Medicine | Louisville | 2010
University of Louisville School of Medicine | Internal Medicine | Louisville | 2010
Residency
University of Louisville School of Medicine | Internal Medicine |
Louisville | 2012
Title(s)
Chief, Division of General Internal Medicine, Palliative Medicine and Medical Education; Associate Residency Program Director, Advisory Dean
Languages
English
Areas of Interest
Gender-Affirming Care for Transgender/Non-Binary People | HIV Pre-Exposure Prophylaxis | Internal Medicine
Certifications
ABIM (2012, 2022)Practice, Specialty or Service
School of Medicine
Associate Professor
Department of Medicine
Awards
Alpha Omega Alpha (2009)
Outstanding Teaching Award (2011)
Outstanding Senior Resident (2012)
Excellence in Teaching Award (2014)
Fellowship in American College of Physicians (2014)
Golden Apple Teaching Award (2016)
Louisville Magazine "Top Docs" (2016, 2017, 2019)
LEO Magazine Readers' Choice - Top Doctor in Louisville (2019, 2021)
Philosophy
"We work collaboratively to create a welcoming environment for all of our patients. Everyone’s health care needs are different, and we work with our patients to create plans that fit their lifestyles."
Contact Info
Locations
UofL Physicians – Primary Care
UofL Health – Chestnut Street Outpatient Center401 East Chestnut Street, Suite 370
Louisville, KY 40202
502-588-4500
UofL Physicians – Internal Medicine
UofL Health – Chestnut Street Outpatient CenterAmbulatory Internal Medicine (Resident Clinic)
401 East Chestnut Street, Suite 310
Louisville, KY 40202
502-588-4720
Patient Comments
Mar 24, 2025
5 out of 5
I am very thankful for the care given to me by my primary physician, Dr. Clayton Smith! He truly cares about my health and well-being. When I had a medical problem recently, he noticed there was a cancellation by a patient, so he called me personally to see if I can fill that time slot, which, of course, I did and was very grateful to know that he was then able to resolve my medical problem.
Mar 16, 2025
5 out of 5
I was so impressed at the time Dr. Smith spent with me, making sure all my questions and concerns were fully addressed. I'm always pleased also at this office how efficiently everything seems to operate. Anytime I have additional questions or concerns, Dr. Smith makes it easy to communicate through My Chart. Very pleased!
Mar 13, 2025
5 out of 5
I had excellent care from my doctor (Clayton Smith, MD).
Mar 9, 2025
5 out of 5
Dr. Smith is kind and caring. He seems to genuinely care about my physical and mental health. I'm glad he's on my medical team.
Mar 3, 2025
5 out of 5
Dr. Smith is a wonderful provider and has been mine for over 6 years. He always asks appropriate questions, listens to concerns, talks me through any changes, refers to specialists if need be, and is well-informed. I recommend him any chance I get as he's brought me so much relief and peace the past six years, and wouldn't rather have any other provider.
Mar 1, 2025
5 out of 5
Dr. Smith is amazing. I truly appreciate how much he and the staff care about their patients.
Feb 27, 2025
5 out of 5
Dr. Smith listens to my questions, concerns and is solutions oriented with my healthcare. I appreciate his straightforward and clear communication.
Feb 3, 2025
5 out of 5
Dr. Smith Is a great doctor.
Feb 2, 2025
5 out of 5
Dr. Smith is the best PCP I have had.
Jan 29, 2025
5 out of 5
Dr. Clayton Smith was referred to me by friends as I am new in Louisville. My expectations were exceptionally met. I felt very confident with Dr. Smith's knowledge and his caring and concern for his patients.
Jan 26, 2025
5 out of 5
I have received very good care from Dr. Smith.
Jan 19, 2025
5 out of 5
I really like Dr. Clayton Smith
Jan 5, 2025
5 out of 5
Dr. Clayton Smith is the best provider ever.
Jan 3, 2025
5 out of 5
I appreciate Dr. Smith, he's always caring and informed about all my health issues.
Dec 28, 2024
5 out of 5
I have the highest regard for Dr. Smith. He is kind and caring. And it's obvious that he is very smart and highly competent.
Dec 17, 2024
5 out of 5
Dr. Clay Smith is the best PCP I ever have had. I work in the medical field and he has the best bedside manners and spends the most time with me as a patient than I ever have had before.
Dec 17, 2024
5 out of 5
Stellar experience. Great staff and provider (Clayton Smith, MD).
Dec 16, 2024
5 out of 5
Dr. Smith is by far the best PCP I've ever been to.
Dec 8, 2024
4.08 out of 5
Dr. Smith is a fantastic doctor and he listens.
Dec 7, 2024
5 out of 5
Dr. Smith is a wonderful doctor.
Nov 20, 2024
5 out of 5
A big thank you to Dr. Smith and his entire staff
Nov 8, 2024
5 out of 5
Always enjoy my visit with Dr. Smith and his staff. They are always respectful and willing to listen to you. Dr. Smith is very professional and will take the time to explain things to you in a way you can understand.
Oct 27, 2024
5 out of 5
Probably the best doctor/ patient relationship that could be expected. Every time I go there, I feel that Dr C. Smith cares about my long term health and I plan to keep going there .
Oct 15, 2024
5 out of 5
Dr. Smith and staff are great. I could not ask for a better primary care doctor. I have a friend who is also a patient of Dr. Smith and she loves him as well.
Oct 13, 2024
5 out of 5
Dr. Smith does an excellent job.
Oct 12, 2024
5 out of 5
Dr. Smith is an excellent GP. Would highly recommend him to anyone.
Oct 9, 2024
5 out of 5
Dr. Smith was awesome.
Sep 21, 2024
5 out of 5
Dr. Smith always listens carefully to whatever I have to say and responds just as carefully as he listened.
Sep 17, 2024
5 out of 5
I love that I don't need to explain my LGBTQ+ lifestyle to my provider. It's so refreshing compared to where I grew up and I will always be thankful for Dr. Smith's care.
Sep 14, 2024
5 out of 5
Dr. Smith is extremely efficient, and I certainly appreciate that fact. I always have a good experience at this office.
Sep 9, 2024
5 out of 5
Dr. Smith is kind and attentive. He listens and gives good feedback. I like that he goes over all medications and asks questions about any changes.
Sep 5, 2024
5 out of 5
Dr. Clayton Smith is a great provider! I always feel like he actually listens to me and cares about my health. He takes the time to address any concerns I might have and doesn't ever make me feel like I'm being rushed out so the next patient can be seen.
Aug 24, 2024
5 out of 5
Dr. Smith is a gift!
Aug 11, 2024
5 out of 5
Dr. Smith and his office team are excellent; I would recommend this provider to any friend of family member.
Aug 8, 2024
4.8 out of 5
Dr. Smith was very thorough in his history taking on this first visit and I am grateful for his interest and actions so far.
Aug 4, 2024
5 out of 5
Dr. Smith is fantastic. Absolutely a delight to have, extremely trustworthy and helpful.
Aug 1, 2024
5 out of 5
I have been very pleased with Dr Smith and with this UofL practice. I believe I receive excellent care, and the office team seem to work well together.
Jul 26, 2024
5 out of 5
Dr. Smith is an excellent and thoughtful provider who always makes me feel like he genuinely cares about my needs.
Jul 20, 2024
5 out of 5
Dr. Smith is a knowledgeable and caring person. I am very lucky to have him as my doctor.
Jul 20, 2024
5 out of 5
I very much enjoy working with Dr. Clay Smith. If I have any concerns or questions, I text via MyChart and he responds quickly. We have an excellent relationship. It is positive and comfortable and healing.
Jul 14, 2024
5 out of 5
Dr. Smith is outstanding!
Jul 11, 2024
5 out of 5
Dr. Smith is a thorough, knowledgeable and compassionate doctor.
Jun 23, 2024
4.6 out of 5
I am apparently doing well with the expert guidance from Dr. Smith. Staying on therapy and contending with ordinary daily stressors is being met.
Jun 15, 2024
4.56 out of 5
I've never met a physician as personable, thorough and with the awesome bedside manner Dr. Clay Smith has. He is an amazing role model for what physicians should be like.
Jun 4, 2024
5 out of 5
Dr. Smith takes excellent care of me.
UofL Physicians participates in most major health plans in Kentucky. Coverage may vary by specialty. Coverage limitations are dependent on the terms of your personal health plan. This is not a guarantee that all services you receive will be covered by your health plan. Review your health plan provider directory and/or consult with your plan to confirm coverage.
